食品科學系

個人資料

姓名： 吳俊毅   
職稱： 教授 
電子郵件： wujy@nqu.edu.tw
聯絡電話： 082-313573

研究領域：醱酵工藝、機能性微生物開發、分離程序、生物代謝轉換、醱酵產品開發

學歷/經歷/榮譽/專業證照

學歷
國立清華大學 化學工程研究所 博士 (1987-1992)
國立清華大學 化學工程學系 學士 (1983-1987)

學術研究經歷
國立金門大學食品科學系 教授 (2019~)
國立金門大學食品科學系 副教授 (2017-2019)
國立金門大學通識教育中心 副教授 (2016-2017)
北京化工大學生物工程學院 訪問研究 (2006)
University of Minnesota 化工系 訪問研究 (1997)
義守大學化工系 副教授 (1995-2016)
教育行政經歷
國立金門大學 教務長 (2016~2022)
義守大學化工系 系主任 (2014-2016，2003-2006)
義守大學教務處 秘書 (2007-2008)
義守大學教務處註冊組 組長 (2001-2003)
產業服務經歷
燁聯鋼鐵股份有限公司 高級工程師 (1994-1995)

2023- 2024  國科會特殊優秀人才獎勵
2023             國立金門大學研究傑出獎
2023             國立金門大學楊宗禮教學傑出獎 (全校前2%)
2023             第一屆BioSFE 2023 (Kuching, Sarawak)最佳論文獎
2022- 2023  國科會特殊優秀人才獎勵
2020- 2021  科技部特殊優秀人才獎勵
2019             國立金門大學研究傑出獎
2014             AFOB國際研討會最佳論文
2014             YABEC國際研討會邀請演講
2012             生化工程研討會優良壁報論文
2010, 2007   義守大學校級優良導師 (全校前2%)
SIGMA Xi 科學研究學會正式會員（Full Member）

實驗室發展方向與研究主題

本研究室為醱酵製程與產品開發實驗室，專注於微生物製程開發與研究，利用菌種篩選、選殖或突變技術開發具功能性的新菌種，進行創新結構化合物、特用化學品、醱酵食品、機能性微生物等生產。實驗室現有設備包括5L醱酵槽、UV/Vis、GC、GCMS、HPLC (with UV/RI/ELSD)、多功能培養箱與微生物操作相關設備。本實驗室研究方向如下：
1. 微生物醱酵最適化
2. 醱酵程序設計與製程優化
3. 生物轉化
4. 生化製程產物之分離純化
5. 醱酵食品開發

實驗室研究發展產品與執行計畫如下：
一、微生物胞內含有具有不同生物轉化酵素，可以進行甲基化、氫氧基位置轉換、脫氫化或醣基化等專一性反應。利用微生物的生物轉化特性，可開發出一些新型藥物，不僅改變化合物的物理化學性質，同時也可以提高其生化活性，本實驗室以具有特殊基因之微生物或基因轉殖方式進行生物轉化程序，並測試這些新型藥物的生理活性與應用，提高其應用廣度。目前實驗室以異黃酮、天然三萜類化合物等具有生物活性物質，進行生物轉化，改變其物理化學性質(如溶解度、耐酸鹼性...)或強化生物活性(抗發炎、抗氧化、腫瘤細胞抑制...)，開發創新結構化合物。
二、結合金門地方農特產和微生物醱酵專業技術，本實驗室開發"金讚高粱味噌"與"金讚高粱豆腐乳"，採用非基因改造黃豆、金門在地高粱、小麥與金門高粱酒，遵循古法釀造。本實驗室致力於菌種篩選與優化醱酵技術，篩取具有高活性蛋白分解酶與澱粉分解酶之優良菌種，經由多次試驗，以特殊技術接入金門在地高粱與小麥上，讓具有高活性麴菌與黃豆充分進行發酵反應，產生多樣胺基酸、寡肽與寡糖，生成多樣小分子營養物，不僅有利於人體吸收，亦可熟成出醇厚濃郁的風味。
三、酒類釀造可分液態醱酵與固態醱酵，傳統高粱酒的製程中大多以固態醱酵為主。固態醱酵製程技術發展與操作調控對於酒類品質舉足輕重，可以左右白酒特殊香味（總酯）、口感（酸、殘糖）與高級醇的生成，居中國白酒發展史很重要的地位。為提升高粱澱粉的利用率與酒精產率，可利用改良式液態醱酵法（以下簡稱半固態醱酵法，Semi-Solid State Fermentation, SSSF）進行高粱酒醱酵，釀程約需7-10天。本實驗室致力於固態醱酵與半固態醱酵法的製程改善、醱酵因子監測、成分歷時分析，以期提高關鍵成分之產率與濃度。

Resume

        Jiumn-Yih Wu received B.S. and Ph.D. degrees from the Department of Chemical Engineering, National Tsing-Hua University, Hsin-Chu, Taiwan, in 1987 and 1992, respectively. He was an Associate Professor at the Department of Chemical Engineering at I-Shou University from 1996 to 2016. During his service at I-Shou University, he served as the Chairman of the Department of Chemical Engineering during the periods from 2003 to 2006 and from 2014 to 2016. He was invited to be a visiting researcher by the University of Minnesota in 1997 and the Beijing University of Chemical Technology in 2006. In 2016 he was appointed to be the Provost of National Quemoy University (NQU), Kinmen, Taiwan. In 2017 he joined the faculty of the Department of Food Science, NQU, where he is now a Full Professor. He served as the Provost with NQU for 6 years, from 2016 to 2022. His conspicuous research performance has led to his appointment as a Distinguished Professor of NQU since 2024. His research interests include fermentation technology, functional microbes development, and biotransformation of bioactive molecules. The efforts for years have been devoted to bioprocess engineering which includes fermentation processing, optimized cultivation of microbial organisms, and biotransformation of triterpenoids and Isoflavones to be active pharmaceutical ingredients.
       Dr. Wu's lab sincerely recruits enthusiastic and ambitious students to join his group to do research and conduct NSTC/KKL projects together. If you are interested in the world of functional microbes and some of the lab's research topics are interesting to you, please feel free to contact Dr. Wu or email via wujy@nqu.edu.tw

Research Expertise

Fermentation Technology, Specific Functional Microbes Development, Separation Technology, Biotransformation, Fermented Foods Development

著作：期刊論文/核准專利/研討會論文

期刊論文

1. Te-Sheng Chang, Hsiou-Yu Ding, Jiumn-Yih Wu, Min-Lin Wang and Huei-Ju Ting*, 2024, "Biotransformation-guided purification of a novel glycoside derived from the extracts of Chinese herb Baizhi", Journal of Bioscience and Bioengineering, 137(1), 47-53.

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   Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Cheng-Zhi Cai and Te-Sheng Chang*, 2023, "Antioxidant and anti-α-glucosidase activities of biotransformable dragon’s blood via predicted data mining approach", Process Biochemistry, 130, 166–173.
3. Hsiou-Yu Ding, Tzi-Yuan Wang, Jiumn-Yih Wu, Yun-Rong Zhang and Te-Sheng Chang*, 2023, "Novel Ganoderma triterpenoid saponins from the biotransformation-guided purification of a commercial Ganoderma extract", Journal of Bioscience and Bioengineering, 135(5), 402-410.

4. ---

   Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Min-Hui Hsu and Te-Sheng Chang*, 2022, "A New Stilbene Glucoside from Biotransformation-Guided Purification of Chinese Herb Ha-Soo-Oh", Plants, 11(17), 2286.
5. Jiumn-Yih Wu, Tzi-Yuan Wang, Hsiou-Yu Ding, Chuan-Che Lee and Te-Sheng Chang*, 2022, "A Novel Soy Isoflavone Derivative, 3'-Hydroxyglycitin, with Potent Antioxidant and Anti-α-Glucosidase Activity", Plants, 11(17), 2202.
6. Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Cheng-Zhi Cai and Te-Sheng Chang*, 2022, "Application of Biotransformation-Guided Purification in Chinese Medicine: An Example to Produce Butin from Licorice", Catalysts, 12(7), 718.
7. Hsiou-Yu Ding, Tzi-Yuan Wang, Jiumn-Yih Wu, Yu-Li Tsai and Te-Sheng Chang*, 2022, "Enzymatic synthesis of novel and highly soluble puerarin glucoside by Deinococcus geothermalis amylosucrase", Molecules, 27(13), 4074.
8. Jiumn-Yih Wu, Hsiou-Yu Ding, Shun-Yuan Luo, Tzi-Yuan Wang, Yu-Li Tsai and Te-Sheng Chang*, 2022, "Novel Glycosylation by Amylosucrase to Produce Glycoside Anomers", Biology, 11(6), 822.

9. ---

   Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Yu-Li Tsai, Huei-Ju Ting and Te-Sheng Chang*, 2021, "Improving Aqueous Solubility of Natural Antioxidant Mangiferin through Glycosylation by Maltogenic Amylase from Parageobacillus galactosidasius DSM 18751”, Antioxidants, 10(11), 1817.
10. Jiumn-Yih Wu, Tzi-Yuan Wang, Hsiou-Yu Ding, Yun-Rong Zhang, Shu-Yuan Lin and Te-Sheng Chang*, 2021, "Enzymatic Synthesis of Novel Vitexin Glucosides", Molecules, 26(20), 6274.
11. Chien-Min Chiang, Tzi-Yuan Wang, Jiumn-Yih Wu, Yun-Rong Zhang, Shu-Yuan Lin and Te-Sheng Chang*, 2021, "Production of New Isoflavone Diglucosides from Glycosylation of 8-Hydroxydaidzein by Deinococcus geothermalis Amylosucrase", Fermentation, 7(4), 232.
12. Luis B. Gómez-Luciano, Yu-Wei Wu, Chien-Min Chiang, Te-Sheng Chang, Jiumn-Yih Wu* and Tzi-Yuan Wang, 2021, "Complete Genome Sequence of the Soil-Isolated Psychrobacillus sp. Strain AK 1817, Capable of Biotransforming the Ergostane Triterpenoid Antcin K", Microbiology Resource Announcements, 10(40), e01242-20. (corresponding author)
13. Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Yun-Rong Zhang and Te-Sheng Chang*, 2021, "Glycosylation of Ganoderic Acid G by Bacillus Glycosyltransferases", International Journal of Molecular Sciences, 22(18), 9744.
14. Te-Sheng Chang, Chien-Min Chiang, Tzi-Yuan Wang, Yu-Li Tsai, Yu-Wei Wu, Huei-Ju Ting and Jiumn-Yih Wu*, 2021, "One-pot Bi-enzymatic Cascade Synthesis of Novel Ganoderma Triterpenoid Saponins", Catalysts, 11(5), 580. (corresponding author)
15. Te-Sheng Chang, Chien-Min Chiang, Jiumn-Yih Wu, Yu-Li Tsai and Huei-Ju Ting*, 2021, "Production of a New Triterpenoid Disaccharide Saponin from Sequential Glycosylation of Ganoderic Acid A by Two Bacillus glycosyltransferases", Bioscience Biotechnology and Biochemistry, 85(3), 687-690.
16. Te-Sheng Chang, Tzi-Yuan Wang, Chien-Min Chiang, Yu-Ju Lin, Hui-Lien Chen, Yu-Wei Wu, Huei-Ju Ting* and Jiumn-Yih Wu, 2021, "Biotransformation of Celastrol to a Novel, Well-soluble, Low-toxic and Anti-oxidative Celastrol-29-O-β-glucoside by Bacillus Glycosyltransferases", Journal of Bioscience and Bioengineering, 131(2), 176-182.

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    Jiumn-Yih Wu*, Te-Sheng Chang, Chien-Min Chiang and Tzi-Yuan Wang, 2020, "Glycosylation of Ganoderic Acid A via Recombinant Glycosyltransferase of Bacillus subtilis Under Acidic Operating Condition", FASEB Journal, Biochemistry and Molecular Biology, Biomolecular Catalysis, 34(S1). (corresponding author)

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    Te-Sheng Chang, Tzi-Yuan Wang, Tzu-Yu Hsueh, Yu-Wen Lee, Hsin-Mei Chuang, Wen-Xuan Cai, Jiumn-Yih Wu, Chien-Min Chiang and Yu-Wei Wu, 2019, "A Genome-Centric Approach Reveals a Novel Glycosyltransferase from the GA A07 Strain of Bacillus thuringiensis Responsible for Catalyzing 15-O-Glycosylation of Ganoderic Acid A", International Journal of Molecular Sciences, 20(20), 5192.
19. Te-Sheng Chang, Chien-Min Chiang, Yu-Han Kao, Jiumn-Yih Wu, Yu-Wei Wu and Tzi-Yuan Wang, 2019, "A New Triterpenoid Glucoside from a Novel Acidic Glycosylation of Ganoderic Acid A via Recombinant Glycosyltransferase of Bacillus subtilis", Molecules, 24(19), 3457.
20. Te-Sheng Chang, Tzi-Yuan Wang, Szu-Yi Yang, Yu-Han Kao, Jiumn-Yih Wu* and Chien-Min Chiang, 2019, "Potential Industrial Production of a Well-Soluble, Alkaline-Stable, and Anti-Inflammatory Isoflavone Glucoside from 8-Hydroxydaidzein Glucosylated by Recombinant Amylosucrase of Deinococcus geothermalis", Molecules, 24(12), 2236. (corresponding author)

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    Te-Sheng Chang*, Horng-Huey Ko, Tzi-Yuan Wang, Chun-Hsien Lee and Jiumn-Yih Wu*, 2018, "Biotransformation of Ganoderic Acid A to 3-O-Acetyl Ganoderic Acid A by Soil-isolated Streptomyces sp.", Fermentation, 4(4), 101. (corresponding author)
22. Te-Sheng Chang, Jiumn-Yih Wu, Tzi-Yuan Wang, Kun-Yuan Wu and Chien-Min Chiang*, 2018, "Uridine Diphosphate-Dependent Glycosyltransferases from Bacillus subtilis ATCC 6633 Catalyze 15-O-Glycosylation of Ganoderic Acid A”, International Journal of Molecular Sciences, 19(11), 3469.
23. Te-Sheng Chang, Chien-Min Chiang, Chun-Hsien Lee, Yu-Wen Lee, and Jiumn-Yih Wu*, 2018, "New Triterpenoid from Novel Triterpenoid 15-O-Glycosylation on Ganoderic Acid A by Intestinal Bacteria of Zebrafish", Molecules, 23(9), 2345. (corresponding author)
24. Chien-Min Chiang , Tzi-Yuan Wang , Szu-Yi Yang, Jiumn-Yih Wu* and Te-Sheng Chang, 2018, "Production of New Isoflavone Glucosides from Glycosylation of 8-Hydroxydaidzein by Glycosyltransferase from Bacillus subtilis ATCC 6633", Catalysts, 8(9), 387. (corresponding author)
25. Te-Sheng Chang, Chien-Min Chiang, Yi-Yun Siao and Jiumn-Yih Wu*, 2018, "Sequential Biotransformation of Antcin K by Bacillus subtilis ATCC 6633", Catalysts, 8(9), 349. (corresponding author)

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    Chien-Min Chiang, Tzi-Yuan Wang, An-Ni Ke, Te-Sheng Chang and Jiumn-Yih Wu*, 2017, "Biotransformation of Ergostane Triterpenoid Antcin K from Antrodia cinnamomea by Soil-Isolated Psychrobacillus sp. AK 1817", Catalysts, 7(10), 299. (corresponding author)
27. Chien-Min Chiang, Yu-Jhe Chang, Jiumn-Yih Wu* and Te-Sheng Chang, 2017, "Production and Anti-Melanoma Activity of Methoxyisoflavones from the Biotransformation of Genistein by Two Recombinant Escherichia coli Strains", Molecules, 22(1), 87. (corresponding author)

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    吳俊毅*，劉志鴻，2014, 己二烯二酸生物精煉與其應用，「化工」，61(2)， 2-10。 (通訊作者)
29. Jing-Ru Liou, Li-Yeh Chuang, Yuan-Han Yang, Tung-Ying Wu, Mohamed El-Shazly, Shyh-Jong Wu, Tusty-Jiuan Hsieh, Yang-Chang Wu, Jiumn-Yih Wu* and Fang-Rong Chang, 2014, "Fast Quantification of S-adenosyl-Lmethionine in Dietary Health Products Utilizing Reversed-Phase High-performance Liquid Chromatography: Teaching an Old Method New Tricks", Planta Medica, 80(2-3), 243-248. (corresponding author)

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    Victor Chia-Hsiang Lin, Ya-Chu Tsai, Jia-Ni Lin, Ling-Ling Fan, Min-Hsiung Pan, Chi-Tang Ho, Jiumn-Yih Wu* and Tzong-Der Way, 2012, "Activation of AMPK by Pterostilbene Suppresses Lipogenesis and Cell-Cycle Progression in p53 Positive and Negative Human Prostate Cancer Cells", Journal of Agricultural and Food Chemistry, 60(6), 6399−6407. (corresponding author)

31. ---

    Chia-Hsiang Victor Lin, Hsiou-Yu Ding, Shiou-Yi Kuo, Ling-Wei Chin, Jiumn-Yih Wu and Te-Sheng Chang, 2011, "Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale", International Journal of Molecular Sciences, 12(8), 4819-4835. (corresponding author)
32. Victor C. Lin, Hsiou-Yu Ding, Pin-Chin Tsai, Jiumn-Yih Wu, Yen-Hsing Lu and Te-Sheng Chang, 2011, "In Vitro and in Vivo Melanogenesis Inhibition by Biochanin A from Trifolium pratense", Bioscience, Biotechnology, and Biochemistry, 75(5), 914-918.

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    Kuan-Yin Hsiao, Jia-Ming Wu, Jiumn-Yih Wu, Shyh-An Yeh and Pei-Ling Tang, 2010, "Development of Bio-dosimeter by Utilization of Radiation Induced Saccharification of Lignocellulose in Radiation Oncology", Taiwanese Journal of Applied Radiation and Isotopes, 6(4), 978-985.

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    Jer-Yiing Houng, Jiumn-Yih Wu, Hsia-Fen Hsu and Jui-Ching Tseng, 2008, "Kinetic Investigation on Asymmetric Bioreduction of Ethyl 4-chloro Acetoacetate Catalyzed by Baker’s Yeast in an Organic Solvent-water Biphasic System", Korean Journal of Chemical Engineering, 25(6), 1427-1433

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    Jer-Yiing Houng, Jia-Hong Liao, Jiumn-Yih Wu, Szu-Chuan Shen and Hsia-Fen Hsu, 2007, "Enhancement of Asymmetric Bioreduction of Ethyl 4-chloroacetoacetate by the Design of Composition of Culture Medium and Reaction Conditions", Process Biochemistry, 42(1), 1-7

36. ---

    Chun-Ming Wu, Chang-Chan Wu, Chien-Chou Su, Sung-Nung Lee, Yung-An Lee and Jiumn-Yih Wu, 2006, "Microbial Synthesis of cis,cis-Muconic Acid from Benzoate by Sphingobacterium sp. Mutants", Biochemical Engineering Journal, 29(1-2), 35-40.

37. ---

    Chun-Ming Wu, Tsung-Huei Lee, Sung-Nung Lee, Yung-An Lee and Jiumn-Yih Wu, 2004, "Microbial Synthesis of cis,cis-Muconic Acid by Sphingobacterium sp. GCG Generated from Effluent of a Styrene Monomer (SM) Production Plant", Enzyme and Microbial Technology, 35(6-7), 598–604.

38. ---

    Jer Yiing Houng, Hsia Fen Hsu, Yung Hau Liu and Jiumn-Yih Wu, 2003, "Applying the Taguchi Robust Design to the Optimization of the Asymmetric Reduction of Ethyl -chloro Acetoacetate by Bakers’ Yeast", Journal of Biotechnology, 100(3), 239-250

核准專利

1. 中華民國專利公告第I837950號「芒果苷醣苷及其製備方法」，2024/04/01~2042/11/15。
2. 中華民國專利公告第I813507號「羥基黃豆黃苷用途」，2023/08/21~2042/11/15。
3. 中華民國專利公告第I812448號「羥基龍血素、其生產方法與用途」，2023/08/11~2042/09/01。
4. 中華民國專利公告第I800179號「靈芝酸糖苷變旋異構物及其生產方法」，2023/04/21~2041/12/22。
5. 中華民國專利公告第I770498號「真菌三萜糖苷化合物及其製備方法」，2022/07/11~2040/04/23。
6. 中華民國專利公告第I663972號「3'-甲氧基染料木黃酮於抑制或治療黑色素瘤之用途」，2019/07/01~2037/03/05。

研討會論文

1. Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Huei-Ju Ting, Che-Chia Tsao and Te-Sheng Chang, 2023.09, "Production of New Bioactive Glycosides Through Glycosylation of Triterpenoids and Flavonoids", 1st International Conference on Biotechnology, Smart Farming and Entrepreneurship for Food Security (BioSFE 2023), Kuching, Sarawak
2. Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang and Te-Sheng Chang, 2023.09, "Finding new compounds via a predicted data mining approach", 2Bp04, The 75th Annual Meeting of the Society for Biotechnology, Nagoya, Japan
3. Te-Sheng Chang, Jiumn-Yih Wu, Tzi-Yuan Wang and Hsiou-Yu Ding, 2023.07, "Inhibition of α-glucosidase by loureirin A and loureirin B", #1013, Biomaterials International 2023, Sapporo, Japan
4. Yu-Li Tsai, Jiumn-Yih Wu, Te-Sheng Chang, Tzi-Yuan Wang and Hsiou-Yu Ding, 2023.07, "Using Biotransformation-guided Purification to Produce New Ganoderma Saponins", 第28屆台灣生物技術暨生化工程 (BEST)國際研討會暨Symposium of Young Asian Biological Engineers' Community (YABEC), PST-01, 台南, 台灣

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   Hsiou-Yu Ding, Jiumn-Yih Wu, Tzi-Yuan Wang and Te-Sheng Chang, 2022.11, "Using Copper-Containing Tyrosinase to Produce 3’-Hydroxyglycitein", The 10th Asian Biological Inorganic Chemistry (AsBIC10), P-37, Kobe, Japan
6. Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Yu-Li Tsai and Te-Sheng Chang, 2022.06, "Glycosylation of Ganoderic Acid F by Amylosucrase from Deinococcus geothermalis", The 13th Asian Federation of Biotechnology Regional Symposium (ARS 2022), P_BB_09, Kinmen, Taiwan
7. Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Yun-Rong Zhang and Te-Sheng Chang, 2022.01, "Novel Ganoderma Saponins from Biotransformation of Ganoderic Acid G", 2021 TwIChE 台灣化學工程學會68週年年會暨科技部化學工程學門成果發表會/前瞻分子工程研討會， 生化及生醫工程， P2-2-001， 高雄， 台灣

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   Te-Sheng Chang, Chien-Min Chiang, Tzi-Yuan Wang, Yu-Li Tsai, Yu-Wei Wu, Huei-Ju Ting and Jiumn-Yih Wu, 2021.10, "Novel Ganoderic Triterpenoid Saponins from Biotransformation of Ganoderic acid A-15-O-Glucoside by Toruzyme ®", 2021 26^th生物技術暨生物工程研討會, Section of Biocatalyst and Protein Engineering, 台中, 台灣

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   Jiumn-Yih Wu, Te-Sheng Chang, Chien-Min Chiang and Tzi-Yuan Wang, 2020.04, "Glycosylation of Ganoderic Acid A via Recombinant Glycosyltransferase of Bacillus subtilis Under Acidic Operating Condition", American Society for Biochemistry and Molecular Biology (ASBMB 2020), San Diego, USA

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    Te-Sheng Chang, Su-Yi Yang, Chien-Min Chiang and Jiumn-Yih Wu, 2019.07, "Biosynthesis of 8-Hydroxydaidzein Glucosides by Recombinant Amylosucrase from Deinococcus geothermalis", The 14th Asian Congress on Biotechnology (ACB 2019), P04-002, Taipei, Taiwan

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    Jiumn-Yih Wu, W.C. Lee and J.Y. Wu, 2018.07, "Effect of Oxygen Transfer on Microbial SAM Production", 18^th European Congress on Biotechnology (ECB 2018), P24-8, Geneva, Switzerland

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    Wen-Feng Sung and Jiumn-Yih Wu, 2017.02, "SAM Preparation from Mutated Yeast", 9^th AFOB REGIONAL SYMPOSIUM (ARS 2017), Manila, Philippines

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    Wen-Feng Sung and Jiumn-Yih Wu, 2016.11, "Effect of Methionine Supplement on SAM Production in Fed-batch Cultivation", 2016年化工年會, BC020, 中壢, 台灣
14. Jiumn-Yih Wu and Wen-Chien Lee, 2016.07, "Enhanced Production and Recovery of Microbial Muconic Acid", 17^th European Biotechnology Congress, Krakow, Poland
15. Jiumn-Yih Wu, Shuang-Yi Hong, Fang-Ru Tung and Ming-Tsai Liang, 2016.06, “Cellulose Hydrolysis by Using [Bmim]Cl Treatment”, 2016 21^st生物技術暨生物工程研討會, 中壢, 台灣
16. Ming-Yao Huang, Jaun-Yann Wu and Jiumn-Yih Wu, 2016.04, "Chemical Treatment to the Separation of Microbial Muconic Acid", 2016 KSBB Spring Meeting and International Symposium, Gyeongju, Korea

17. ---

    Wen-Ling Chen, Shuang-Yi Hong, Fang-Ru Tung, Ming-Tsai Liang and Jiumn-Yih Wu, 2015.11, "Ionic Liquid Application to Cellulose Hydrolysis", 2015 Taiwan/Korea/Japan Joint Meeting on Chemical Engineering, P1-043, Kaohsiung, Taiwan
18. Ming-Yao Huang, Po-Chen Pan and Jiumn-Yih Wu, 2015.06, "Improved Fed-batch Cultivation of Microbial Muconic Acid"，2015 20^th生物技術暨生物工程研討會， P1-T1-5, 台北, 台灣
19. Wen-Feng Sung and Jiumn-Yih Wu, 2015.01, "Effect of Operating Parameters on SAMe Fermentation", 2015生物資源與科技研討會, pp138, 台南, 台灣

20. ---

    蕭介夫, 梁明在, 黃明耀, 陳佩汝, 吳俊毅, 2014.12, "The Applications of Simulated Moving Bed in the Separation of Hyaluronic Acid with Different Molecular Weight", 2014年化工年會, C_P_Y002, 中壢, 台灣
21. Jiumn-Yih Wu, 2014.11, "Biological Production of Muconic Acid”, 2014海峽兩岸生質能源與生物精煉研討會， pp.23-24, Chiayi, Taiwan
22. Po-Chen Pan, Ming-Yao Huang, Chih-Yuan Chang and Jiumn-Yih Wu, 2014.11, “Succinate Supplement for Muconic Acid Fed-batch Production”, 20^th Symposium of Young Asian Biochemical Engineers' Community, pp.203, Chiayi, Taiwan
23. Po-Chen Pan, Ming-Yao Huang, Chih-Yuan Chang, Jau-Yann Wu and Jiumn-Yih Wu, 2014.08, “Effect of Yeast Extract Addition in Fed-batch Cultivation on Muconic Acid Fermentation”, Bioenergy and Biorefinery Division Annual Meeting and Bioenergy and Biorefinery Summit 2014, pp.123, Jinan, China
24. Wen-Feng Sung, Li-Yi He and Jiumn-Yih Wu, 2014.06, "Effects of Operating pH and Temperature on SAMe-Producing Strain Fermentation"，2014 19^th生物技術暨生物工程研討會， pp.187, 台中，台灣

25. ---

    Tzu-hsien Wang and Jiumn-Yih Wu, 2013.12, "The Inhibitory Effect of Muconate on Microbial Transformation Activity in Muconic Acid Fermentation", Asian Congress on Biotechnology 2013, New Delhi, India
26. Jiumn-Yih Wu, Zhi-Hong Liu, Zheng Xiong Lin and Po-Chen Pan, 2013.08, "The effect of C/N ratio in the nutrients on microbial transformation activity in muconic acid fermentation", 19^th Symposium of Young Asian Biochemical Engineers' Community, pp.107, Xinjiang, China
27. 林政雄, 潘柏辰, 劉金茹, 楊淵韓, 張芳榮, 莊麗月, 吳俊毅, 2013.06, "S-Adenosyl-L-Methionine 生產菌開發與醱酵條件探討", 2013 18^th生物技術暨生物工程研討會， pp.79， 雲林，台灣
28. Jiumn-Yih Wu, 2013.01, "Biological Transformation of Muconate from Benzoate with Application of Fed-batch Cultivation”, 4^th AFOB Regional Symposium, pp.42, Thailand

29. ---

    Jau-Yann Wu, Jer-Yiing Houng and Jiumn-Yih Wu, 2012.10, "Microbial Production of Muconic Acid by Fed-Batch Culture with Enhanced Oxygen Transfer", International Forum on Industrial Bioprocesses, pp.206, Taipei, Taiwan
30. Jau-Yann Wu and Jiumn-Yih Wu, 2012.09, "Strain Development for cis-cis Muconic Acid Production from Benzoic Acid", International Biotechnology Symposium, pp.301, Daegu, Korea
31. 林政雄, 劉志鴻, 吳俊毅, 2012.06, "產物回饋抑制對己二烯二酸醱酵之影響," 2012 第十七屆生化工程研討會, pp.139, 高雄, 台灣

32. ---

    Jiumn-Yih Wu, 2011.10, "Optimized Medium Design for Muconic Acid Production", The 17^th Symposium of Young Asian Biochemical Engineers' Community, B-28, pp.60, Incheon, Korea
33. Jiumn-Yih Wu, 2011.08, "Biological Production of Muconic Acid", 2^nd AFOB Regional Symposium, pp.58, Mongolia
34. 蘇殷只, 王迺詒, 洪詩婷, 曾清桂, 吳俊毅, 2011.06, "基質設計與凍乾條件對Lactobacillus reuteri活性之影響", 2011年第十六屆生化工程研討會, pp.109, 台北, 台灣
35. 吳俊毅, 王新惠, 劉志鴻, 洪偉庭, 鐘少華, 2011.05, "醋酸乙烯聚酯之微生物汙染與其防治方式", 中國化學會高雄分會2011年會, pp.80, 高雄, 台灣

36. ---

    Jiumn Yih Wu, Sin Yu Yeh and Ching-Guey Tseng, 2010.11, "Microbial Production of Muconic Acid", The 16^th Symposium of Young Asian Biochemical Engineers' Community, A-48, pp.22, Taoyuan, Taiwan
37. 吳俊毅, 謝尚錡, 2010.11, "以回應曲面法建立不銹鋼304伸長率最佳化之冷軋生產條件", 2010年材料年會, 09-0017, pp.246, 高雄, 台灣
38. 蘇殷只, 王迺詒, 洪詩婷, 曾清桂, 吳俊毅, 2010.06, "不同誘導物對Trichoderma reesei Rut C-30代謝內切型纖維酶之影響", 2010年第十五屆生化工程研討會, pp.171, 台南, 台灣
39. 賴惠瑜, 柯欣妤, 吳俊毅, 2010.5, "己二烯二酸醱酵產物之分離與純化", 中國化學會高雄分會2010年會, pp.119, 台南, 台灣

40. ---

    Jiumn Yih Wu, Ching-Guey Tseng and Huei-Yu Lai, 2009.12, "Ethanol Production by Hydrolysate of Corn Stover", The 15^th Symposium of Young Asian Biochemical Engineers' Community, Xiamen, China
41. 吳俊毅, 謝尚錡, 2009.11, "以回應曲面法建立不銹鋼430光澤度最佳化之冷軋生產條件", 2009年材料年會, pp.311, 花蓮, 台灣
42. 吳俊毅, 蔡世和, 2009.11, "以回應曲面法進行隱甲藻生產二十二碳六烯酸培養基最適化之研究", 2009年化工年會, pp.22, 台中, 台灣
43. 吳俊毅, 曾清桂, 潘致平, 2009.06, "以回應曲面法進行Pseudomonas sp.生產己二烯二酸之培養基最適化", 2009年第十四屆生化工程研討會, pp. 105, 台中, 台灣

44. ---

    Jiumn-Yih Wu, Ching-Guey Tseng and Huei-Yu Lai, 2008, "Effect of Dual-substrate on Cellulosic Ethanol Production", 2008 Taiwan/Korea/Japan Chemical Engineering Conference and 55^th Taiwan Institute of Chemical Engineers Annual Conference, Taipei, Taiwan
45. Jiumn-Yih Wu, Ching-Guey Tseng and Huei-Yu Lai, 2008, "Substrate Effect on Cellulosic Ethanol Production," The 14^th Symposium of Young Asian Biochemical Engineers' Community, Japan
46. 曾清桂, 潘致平, 劉祐安, 吳俊毅, 2008, "培養基及操作條件對己二烯二酸發酵之影響", 第十三屆生化工程研討會, PI-67, 139,中壢，台灣
47. 吳俊毅, 2008, "微生物幾丁聚醣分子量變化與培養基質濃度之關係模式", 2008年幾丁質與幾丁聚醣研討會, P50, 台南，台灣

48. ---

    趙恩生, 吳俊毅, 2007, "透明質酸醱酵之饋料批次策略", 第十二屆生化工程研討會, 23, 台北，台灣

49. ---

    Jiumn-Yih Wu and Hua-Bing Chen, 2006, "Effects of Medium Composition on the Production of Microbial Hyaluronic acid", 12^th Young Asian Biochemical Engineers’ Community Symposium, 86, Kaohsiung, Taiwan
50. 鄧棨中, 吳俊毅, 2006, "剪應力與氧氣質傳對於獸疫鏈球菌培養之影響", 第十一屆生化工程研討會, P7-029, 新竹，台灣
51. 曾清桂, 吳俊毅, 林冠宏, 翁愫霙, 2006, "己二烯二酸生產菌株之突變與篩選策略", 第十一屆生化工程研討會, P7-047, 新竹，台灣
52. 陳華彬, 王培銘, 吳俊毅, 2006, "微生物醱酵生產透明質酸之最佳化基質探討", 第十一屆生化工程研討會, O7-001, 新竹，台灣
53. Jiumn-Yih Wu, 2005, "Purification and Characterization of Microbial Chitosan", The 11^th Young Asian Biochemical Engineers’ Community Symposium, 89, Beijing, China

54. ---

    謝誌鴻, 吳俊毅, 陳華彬, 2005, "基質中碳源對Strepcotoccus醱酵的影響", 第十屆生化工程研討會, 1-P-068, 台北，台灣
55. 吳俊毅, 林見恩, 2005, "真菌幾丁聚醣純化之探討", 台灣幾丁聚醣研討會, 24~27, 台南，台灣
56. Chun-Ming Wu, Sung-Nung Lee, Yung-An Lee, Jau-Yann Wu and Jiumn-Yih Wu, 2005, "Biological Synthesis of cis,cis-Muconic Acid", The 7^th Asia-Pacific Biochemical Engineering Conference 2005, Jeju island, Korea

57. ---

    Jiumn-Yih Wu and Jen-Tsai Liu, 2004, "Effects of Supplemental Divalent Ions and N-Acetyl-D-Glucoseamine in Nutrient Medium on Microbial Chitosan Production", The 10^th Young Asian Biochemical Engineers’ Community Symposium, 47, Osaka, Japan
58. 吳俊毅, 劉仁材, 2004, "基質中添加兩價離子對微生物幾丁聚醣生產之影響", 第九屆生化工程研討會, 1, 彰化，台灣
59. 吳俊毅, 劉仁材, 2004, "兩價離子對微生物幾丁聚醣分子量之影響", 幾丁質幾丁聚醣研討會, C190-C193, 雲林，台灣

60. ---

    Jiumn-Yih Wu, Chian-Fang Jeng, Yi-Ru Lin, Yea-Shyuan Yang, Sung-Nung Lee and Charlie Wu, 2003, "Green Production of cis,cis-Muconic acid", The 9^th Young Asian Biochemical Engineers’ Community Symposium, Jeiju Island, Korea.

61. ---

    吳俊毅, 許昺奇, 彭育平, 朱宏哲， 2002, "三段式養豬廢水處理之曝氣系統改善評估"， 第二十七屆廢水處理技術研討會, W-D-P01, 台北，台灣
62. 吳俊毅, 2002, "幾丁聚醣醱酵之最適條件研究", 第七屆生化工程研討會, 1117-1122, 台北，台灣

63. ---

    Jiumn-Yih Wu, 2001, "Substrate Effects of C/N Ratio on Chitosan Fermentation", The 7th Young Asian Biochemical Engineers’ Community Symposium, Shanghai, China.
64. 王薏婷, 吳俊毅, 楊富涵, 2001, "幾丁聚醣醱酵之成本探討", 幾丁質幾丁聚醣研討會, 102-103, 台北，台灣
65. 謝志鴻, 吳俊毅, 黃慶丰, 2001, "氮源量對幾丁聚醣產量之影響", 第六屆生化工程研討會, 211-214, 中壢，台灣

66. ---

    Jiumn-Yih Wu and Z-H Hsien, 2000, "Substrate Effects on Chitosan Fermentation", The 6^th Young Asian Biochemical Engineers’ Community Symposium, Fukuoka, 74-75, Japan
67. 張明群, 吳昭燕, 吳俊毅, 李昌憲, 2000, "氣舉式反應器中進行三相反應之研究", 第五屆生化工程研討會, 273-276, 台南，台灣
68. 鄭家昇, 吳俊毅, 李昌憲, 2000, "基質對幾丁聚醣醱酵的影響", 第五屆生化工程研討會, 269-272, 台南，台灣
69. 黃宏彰, 吳俊毅, 謝志鴻, 2000, "幾丁聚醣醱酵過程中分子量變化之探討", 第五屆生化工程研討會, 265-268, 台南，台灣

執行計劃案：科技部一般型專題研究計畫/科技部國家型-產學聯盟計畫/產學合作計畫/教育部計畫

1. 以生物轉化製備新穎萜類與類黃酮醣苷分子之酵素催化平台(112-2221-E-507-001-， 2023/08/01~2024/07/31)， 計畫主持人。

2. ---

   三萜與黃酮類分子醣苷化生成新型皂苷之研究 (111-2221-E-507-001-， 2022/08/01~2023/07/31)， 計畫主持人。
3. 以醣水解酶生產靈芝皂苷與多醣皂苷之研究 (111-2221-E-024-001-MY3，2022/08/01~2025/07/31)， 共同主持人。

4. ---

   以醣苷酵素催化生產新型三萜醣苷化合物之研究 (110-2221-E-507-002-， 2021/08/01~2022/07/31)， 計畫主持人。
5. 靈芝皂苷之生產與生物活性研究 (110-2221-E-024-002-， 2021/08/01~2022/07/31)， 共同主持人。

6. ---

   利用Bacillus菌株發酵優化生產新穎糖基化三萜及糖基化異黃酮 (108-2221-E-507-008-， 2019/08/01~2020/07/31)，計畫主持人。
7. 新三萜分子之生產與生物活性研究 (108-2221-E-024-008-MY2，2019/08/01~2021/07/31)，共同主持人。

8. ---

   牛樟芝三萜成分之微生物轉換研究 (107-2221-E-024-005-，2018/08/01~2019/07/31)，共同主持人。

9. ---

   機能性酵母菌強化SAM產量之策略研究 (106-2221-E-507-006-， 2017/08/01~2018/07/31)，計畫主持人。
10. 以兩步驟生物轉換生成鄰位氫氧基多酚與甲氧基多酚及其在抑制黑色素生成之研究 (106-2221-E-024-014-，2017/08/01~2018/07/31)，共同主持人。

11. ---

    提高機能性酵母菌之SAM與GSH產量策略研究 (105-2221-E-214-035-，2016/08/01~2017/07/31)，計畫主持人。

12. ---

    功能性酵母菌之菌種開發與研究 (104-2221-E-214-044-，2015/08/01~2016/07/31)，計畫主持人。

1. 台金鏈結之農食檢測技服平台聯盟(3/3) (111-2622-8-507-001-TB1，2022/02/01~2023/01/31)，共同主持人。

2. ---

   台金鏈結之農食檢測技服平台聯盟(2/3) (110-2622-8-507-001-TB1，2021/02/01~2022/01/31)，共同主持人。

3. ---

   台金鏈結之農食檢測技服平台聯盟(1/3) (109-2622-8-507-001-TB1，2020/02/01~2021/01/31)，共同主持人。

4. ---

   連續式醱酵反應器與層析精煉製程整合與開發及其在生質琥珀酸之應用(1/3) (106-3114-E-214-001-，2017/06/01~2018/05/31)，共同主持人。
5. 工業層析分離純化技術產業應用與深耕計畫(4/4) (105-2218-E-214-001-，2016/11/01~2017/10/31)，共同主持人。
6. 模擬移動床技術於生質能源轉化程序之應用(3/3) (105-3113-E-214-001-，2016/01/01~2016/12/31)，共同主持人。

7. ---

   工業層析分離純化技術產業應用與深耕計畫(3/4) (104-2218-E-214-001-，2015/11/01~2016/10/31)，共同主持人。
8. 模擬移動床技術於生質能源轉化程序之應用(2/3) (104-3113-E-214-001-，2015/01/01~2015/12/31)，共同主持人。

9. ---

   工業層析分離純化技術產業應用與深耕計畫(2/4) (103-2218-E-214-001-，2014/11/01~2015/10/31)，共同主持人。

10. ---

    工業層析分離純化技術產業應用與深耕計畫(1/4) (102-2218-E-214-002-，2013/11/01~2014/10/31)，共同主持人。

11. ---

    生質特用化學品製造技術研發 (經濟部科專計畫， EC-17-A-09-S1-206，2012/01/01~2016/12/31)，共同主持人。

產學合作計畫

1. 金酒教育訓練課程「酒類釀造原理與基礎」(2023/12/06-2023/12/07)，計畫主持人。
2. 「金酒公司半固態醱酵製程因子分析與操作評估」(2023/02/06-2024/02/05)，計畫主持人。

3. ---

   111年度CITD (Conventional Industry Technology Development)「水溶性高純度靈芝三萜開發計畫」(2022/08/20-2023/04/30)，共同主持人。

1. 112年度「精準健康產業跨領域人才培育計畫」-「食品創新」 (2023/02/01-2024/01/31)，協同主持人。

2. ---

   111年度「精準健康產業跨領域人才培育計畫」-「食品創新」 (2022/02/01-2023/01/31)，協同主持人。

3. ---

   110年度「生醫產業與新農業學產研鏈結人才培育計畫」A類 -「食品科技產業創新」 (110C016，2021/02/01-2022/01/31)，協同主持人。

4. ---

   109年度「生醫產業與新農業跨領域人才培育計畫」A類 -「生醫產業與新農業學產研鏈結人才培育計畫」 (109C012，2020/02/01-2021/01/31)，協同主持人。
5. 109年度「璀璨雙星計畫」 - 6-1漁產加工與海洋生物科技 (2020/01/01-2020/12/31)，協同主持人。

專業服務

專業期刊審查

Arabian Journal of Chemistry
Biochimica et Biophysica Acta- Molecular Basis of Disease
Bioresource Technology Reports
Biotechnology and Applied Biochemistry
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Biotechnology Journal
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Chemical and Biological Technologies in Agriculture
Enzyme and Microbial Technology
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Food and Bioprocess Technology
Food and Bioproducts Processing
Heliyon
International Journal of Biological Macromolecules
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Journal of Zhejiang University: Science B
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Scientific Reports
World Journal of Microbiology and Biotechnology

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2023               Guest Editor of Special Issue of Process/MDPI
2023               第28屆 台灣生物技術暨生化工程國際研討會學術委員學術委員
2023               2023 Symposium of Young Asian Biological Engineers' Community (YABEC) 學術委員
2023               國立高雄師範大學「白酒製程」學分班授課教師
2023               Guest Editor of Special Issue of Fermentation/MDPI
2022- 2026     Asian Federation of Biotechnology (AFOB) Taiwan Executive Board Member
2022- 2025     台灣生物技術與生化工程學會(BEST)理事
2022               金門高中課程發展委員會專家代表
2021- 2022     台南市環境保護局審查委員
2021               第26屆台灣生物技術暨生物工程國際研討會 Biocatalysts and Protein Engineering 主持人
2021               Catalysts/MDPI (IF 4.146) Editorial Board
2021               義守大學核心計畫審查委員
2020, 2018     金門酒廠研究計畫評審委員
2019- 2022     台灣生物技術與生化工程學會(BEST)理事
2017               中華工程教育學會(IEET)認證委員
2017- 2022     勞動部「醱酵生物技術應用實務班」講師
2015- 2018     經濟部技術處SBIR民生化工領域審查委員
2009               環保署環保科技園區入區審查委員
2007- 2009     中國化學會高雄分會理事
2004- 2011     南部環保科技園區審查與諮議委員
2003- 2015     自強基金會「醱酵工程與規模放大」課程講師
1999- 2005     農委會委託畜牧污染防治輔導
1998- 2003     環保署工廠空氣污染評鑑委員
大學教師升等審查委員
大學碩(博)士班研究生口試審查委員

委辦會議

2022                主辦The 13^th AFOB Regional Symposium (ARS 2022)
2015, 2006      主辦台灣化工年會
2015                主辦台韓日三國化工會議
2006                主辦亞太青年生化工程國際研討會(YABEC)